SPECTROSCOPIC STUDIES OF NEWLY SYNTHESIZED STEROIDAL PYRROLES

Acute Toxicity and Gastroprotection Studies with a Newly Synthesized Steroid

BACKGROUND Synthetic steroids, such as 9α-bromobeclomethasonedipropionate, have shown gastroprotective activity. For example, the potent glucocorticoid steroid, beclomethasone dipropionate, has been used for treatment of bowel ulcerations. The purpose of the present study was to evaluate the effect of a synthetic steroid, (20S)-22-acetoxymethyl-6β-methoxy-3α,5-dihydro-3'H-cyclopropa[3α,5]-5α-pr...

Newly Synthesized Vasorelaxant

Effects of ER-001533 (ER), a newly synthesized vasorelaxant, on the membrane currents were examined in single ventricular cells of guinea pigs. The patch-clamp technique was used in the "whole-cell" and "inside-out" patch configurations. In the whole-cell clamp condition, ER induced a time-independent K'-dominant current, which was inhibited by glibenclamide (1-3 ,uM), suggesting that ER activa...

Degradation of newly synthesized collagen.

Explants of rabbit lung parenchyma maintained in serumfree medium incorporate I 14Clproline and I Wllysine into collagen as I “Clhydroxyproline and I Wlhydroxylysine at a constant rate for at least 24 h. Evaluation of the size distribution of the [14Clhydroxyproline and [‘4Clhydroxylysine containing peptides within the explants demonstrated that 20 to 40% of the LY chains of newly synthesized c...

Raman Spectroscopic Studies of Bioactive Materials

Bioactive materials including glass and glass-ceramics are nowadays used as medical implants for orthopedic applications. In this study several samples of glass-ceramics have been prepared using both heat treatment and sol-gel processes. The structure and bioactivity of these samples based on their interaction with simulated body fluid (SBF) have been determined. In-vitor, using the Raman s...

Intracellular Cleavage of Newly Synthesized Low Affinity